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Myc Miz-1

According to the World Health Organization, cancer is the second leading cause of death globally, responsible for an estimated 9.6 million deaths in 2018. The dysregulation of the oncoprotein c-Myc is a feature of many cancers, including medulloblastoma, colon cancer and leukemias. However, c-Myc is generally considered to be a challenging target because it lacks a druggable domain. In fact, despite the centrality of its role, none of the efforts to modulate c-Myc have shown clinical success to date.